Aspirin may help older colon cancer patients live longer

NEW YORK (Reuters Health) – Older adults with colon cancer who were prescribed a daily aspirin were less likely to die than those who weren’t, according to a new study.

While the results need to be confirmed with more rigorous studies, they add to the evidence linking aspirin use to longer survival for cancer patients. Studies have also suggested the inexpensive drug can prevent some types of the disease from occurring in the first place.

Medical guidelines currently endorse the use of low-dose aspirin to prevent heart disease, but not to fight or prevent cancer.

The new study, published in the Journal of the American Geriatrics Society, included more than 500 colon-cancer patients in the Netherlands aged 70 and older. More than 100 were prescribed daily low-dose “baby” aspirin for heart protection after their cancer diagnosis.

Between 1998 and 2007, the death rate for those prescribed aspirin was about half that of the non-aspirin users. The effect was biggest in people with more advanced cancer and in those who received no chemotherapy.

Anything that might improve survival in elderly adults with colon cancer would be welcome, since there is no consensus on whether to use chemotherapy in those patients, according to the study.

Previous studies have also associated aspirin use with increased survival. Research published in October in the New England Journal of Medicine suggested that aspirin therapy could extend survival for colon cancer patients whose tumors had a specific genetic mutation.

Still, more scientifically rigorous randomized controlled trials will be needed to confirm the findings of studies that are based on observation after the fact, and therefore less definitive about what actually causes the effect seen.

“We’re pretty sure this is a real effect, but we’re not sure of the magnitude,” said Dr. Gerrit Jan Liefers of Leiden University Medical Center in the Netherlands, an author of the new study. He said he didn’t expect randomized trials would show such a large survival advantage. Liefers is working to develop such a trial in the Netherlands.

One limitation of the study is that it looked at aspirin prescriptions, not actual use of the drug. (Low-dose aspirin for heart-disease protection isn’t available over the counter in the Netherlands.) It’s possible that heart benefits from aspirin might have helped the patients live longer, but the study authors said that alone couldn’t account for the big difference in death rates. Also, there might be differences between the groups unaccounted for by researchers that led to the improved survival among the aspirin users.

Liefers said it’s not completely clear how aspirin might combat colon cancer. One likely route: blocking the enzyme cyclooxygenase-2, or COX-2, which is involved in inflammation and is expressed in about 70 percent of colon tumors.

Boris Pasche, director of the hematology and oncology division at the University of Alabama at Birmingham, said it would be helpful to figure out who would benefit from and who could skip daily aspirin.

“It’s a fairly benign drug, but it has side effects,” including bleeding in the gastrointestinal tract and the brain, Pasche said.

He said patients should discuss with their physicians whether it makes sense to take aspirin at this point. “This supports the concept, but we need a prospective randomized trial,” he said.

SOURCE: http://bit.ly/TFEnSF Journal of the American Geriatrics Society, online November 23, 2012.

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Rent a Satellite and Do Science in Space

The size of a typical satellite ranges from small car to truck. The cost ranges from $ 500 million to $ 2 billion. And the weight goes from 1,000 pounds on up to a couple of tons. So these are pretty big devices, and they tend to hang around in space for 10 to 20 years.

When Peter Platzer, a high-energy physicist, looks up at the sky and thinks about these devices, his mind drifts back to the 1960s and the era of mainframe computers. He sees large, expensive machines that perform a limited set of functions for a limited set of customers. But he believes that the technology now exists to change this equation and make a smaller satellite that people can tweak to handle all kinds of tasks.

To back up his vision, Platzer last year started NanoSatisfi. It’s a tiny company operating for the moment out of a warehouse in San Francisco—part of the Lemnos Lab collective—that’s putting together a nano satellite people can rent. The satellite that NanoSatisfi intends to shoot into space is shaped like a cube and weighs a few pounds at the most. It’s packed full of dozens of sensors, including cameras, a Geiger counter, a spectrometer, and a magnetometer, all of which talk to open-source Arduino computer controllers that can be remotely programmed from Earth.

Platzer expects students, hobbyists, and researchers to rush at the chance to create experiments that can run on NanoSatisfi satellites. His team has written software that lets people test their applications on a practice satellite and then upload their programs to the real thing. The company plans to rent time on its satellites for about $ 250 per week and can have multiple people using the device at the same time. “Each satellite can support about 4,000 customers over a five-month period,” Platzer says.

Through a company called NanoRacks, NanoSatisfi has bought space for a pair of satellites that will go up next year on rockets that are resupplying the International Space Station. All told, NanoSatisfi expects to spend well under $ 1 million to build its satellites, get them in space, and operate them for two years, at which point the satellites will drift back toward Earth and burn up in the atmosphere.

The NanoSatisfi work is getting under way at a time when the U.S.’s aging satellite system, used for things like monitoring the weather, has come in for criticism. “I think small satellites could be a true alternative here,”  Platzer says.

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Ghana election, test of democratic reputation

ACCRA, Ghana (AP) — Voters in Ghana were selecting their next president and a 275-seat parliament in elections Friday, solidifying the West African nation‘s reputation as a beacon of democracy in the region.

Some 14 million people are expected to turn out. President John Dramani Mahama, in office for only five months, is running against seven contenders. A former vice president, Mahama became president in July after the unexpected death of former President John Atta Mills. The 54-year-old is also a former minister and parliamentarian and has written an acclaimed biography, “My First Coup d’Etat.”

His main challenger is Nana Akufo-Addo, a former foreign minister and the son of one of Ghana’s previous presidents. The contender lost the 2008 election to Mills by less than 1 percent. Both men are trying to make the case that they will use the nation’s newfound oil wealth to help the poor.

Ghana, a nation of 25 million, is one of the few established democracies in the region as well as the fastest-growing economy. But a deep divide still exists between those benefiting from the country’s oil, cocoa and mineral wealth and those left behind financially.

In an interview on the eve of the vote, Akufo-Addo told The Associated Press that the first thing he will do if elected is begin working on providing free high school education for all. “It’s a matter of great concern to me,” he said, adding that he plans to use the nation’s oil wealth to educate the population, industrialize the economy and create better jobs for Ghanaians.

Policy-oriented and intellectual, Akufo-Addo is favored by the young and urbanized voters. He was educated in England and comes from a privileged family. The ruling party has depicted him as elitist, which Akufo-Addo calls “a little PR construct.”

“The idea that merely because you are born into privilege that automatically means you are against the welfare of the ordinary people, that’s nonsense,” he said.

Ghana had one of the fastest growing economies in the world in 2011. Allegations of corruption against the ruling party are rife.

Akufo-Addo said that if elected, he would not be able to weed out corruption in the government overnight.

“It’s a long fight,” he said. “But we build the institutions that can fight it.”

He said that in 30 years in politics he has never been accused of corruption.

Many analysts believe Mahama and Akufo-Addo are neck-and-neck.

Results are expected to be announced by Sunday, but could be delayed. If no one wins an absolute majority, a second round of voting will be held on December 28.

All candidates have signed a peace pact and have promised to accept the results of Friday’s poll.

Ghana, a nation of 25 million, has previously held five transparent elections in a row. Nearby Mali, which was also considered a model democracy, was plunged into chaos this March following a military coup.

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Associated Press writer Francis Kokutse contributed to this report from Accra, Ghana.

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Apple to return some Mac production to U.S. in 2013: report

(Reuters) – Apple Inc is planning to bring back some of its production of Mac computers to the United States from China next year, Chief Executive Tim Cook said, according to a report published Thursday.

The company will spend more than $ 100 million to build the computers in the United States, Cook was cited as saying in an interview with Bloomberg Businessweek.

“This doesn’t mean that Apple will do it ourselves, but we’ll be working with people and we’ll be investing our money,” Cook said.

He told NBC in an interview to be aired late Thursday that only one of the existing Mac lines would be manufactured exclusively in the United States.

Higher-tech products are largely made overseas, often in subcontracted factories not owned by the brands whose products they are making.

Cheaper labor costs have been key in encouraging U.S. manufacturers to have move production to China, but with Chinese wage and transport costs increasing, the advantage against the U.S. has narrowed in recent years.

(Reporting by Nicola Leske; Editing by Bernadette Baum)

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“Community”: Jason Alexander filming “Crazy” guest spot

LOS ANGELES (TheWrap.com) – “Community” might be losing a Chevy Chase, but it’s gaining a Jason Alexander.

Former “Seinfeld” star Alexander, who played neurotic bumbler George Costanza on the series, will guest-star on the beleaguered NBC comedy, and while the actor is tight-lipped on the details, he promises that the episode will be a doozy.

“Filming a crazy episode of ‘Community’ this week,” the actor tweeted early Tuesday. “Can’t say much about it but it’s a fun one.”

It is not known what role Alexander, who guest-starred on “Two and a Half Men” earlier this year, will play on the series, or if he will appear on more than one episode. A spokeswoman for the NBC series has not yet responded to TheWrap’s request for comment.

Last month, news broke that Chevy Chase – who plays Pierce Hawthorne on the series – is leaving “Community,” following an ugly standoff with the show’s creator and former showrunner, Dan Harmon, and an incident when he reportedly tossed out the N-word, after complaining about his character’s racism. Chase will appear in most of the episodes of the upcoming fourth season.

“Community” returns to the air February 7.

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When Microorganisms Control the Mind

Reported by Dr. Lauren Browne:

By the time famed Victorian artist Louis Wain was committed to the pauper ward of Springfield Mental Hospital in South London in 1924, he had painted and sketched thousands of cats.

His early works depicted humorous wide-eyed human-like cats, but his later feline creations were abstract figures exploding in fiery kaleidoscopes of geometric shapes, thought to mirror his own mental deterioration.

The exact nature of Wain’s mental illness is still debated, but many agree that he suffered from schizophrenia, becoming hostile and delusional prior to hospitalization.  And some speculate further that it was a parasite from one of his beloved cats that ultimately triggered his schizophrenic break.

Bugs that hijack the brain and manipulate behavior are now the focus of a special newly released edition of The Journal of Experimental Biology.  This collection of review articles tips its hat to the ever-growing body of research devoted to the field of neuroparasitology, a field where “science meets science fiction,” according to journal editor Michael Dickinson.

Wain’s psychosis was thought to be caused by Toxoplasma gondii, a parasite that infects humans after exposure to cat feces, and is well known for causing dementia and delirium in people with weak immune systems, like in advanced AIDS.  Yet even in relatively healthy individuals, it appears that the parasite can manipulate human behavior.

Silent, or asymptomatic, infections have been linked to increased risk of traffic and workplace accidents as well as mood and neurological disorders, including Parkinson’s disease, Alzheimer’s disease, schizophrenia, bipolar disorder, and even suicide, according to several studies reviewed by Joanne Webster and colleagues of the Imperial College of London.

“Some studies have shown that when you look at people who have a history of some sort of mental illness, a higher percentage of them have a higher exposure to toxoplasmosis.  That’s an intriguing thing,” said Dr. Anthony Fiore, director of science for the CDC’s Division of Parasitic Diseases.

No studies have yet proven that the infection actually causes mental illness and in all likelihood it is a combination of factors that trigger schizophrenia or other illnesses, said Fiore.

But toxoplasma is just one of many microorganisms that have the potential to manipulate the human brain.

The rabies virus, which is largely transmitted through dog bites and is responsible for over 55,000 human deaths around the world each year, is particularly fond of infecting the brain.  It has the ability to catapult its victims into a downward psychotic spiral of delirium, hallucinations, and aggression that almost uniformly ends in death.

“A patient in Manila went on a rampage and attacked multiple people, beating people with wood, and causing quite a lot of physical destruction,” said Dr. Charles Rupprecht, a leading rabies expert and director of research of The Global Alliance for Rabies Control.

The rabies virus is just one member of a group of deadly, brain-loving viruses known as Lyssaviruses, named after the Greek goddess of madness, rage, and frenzy.   These almost universally lethal viruses are currently only transmitted to humans through animals and, with the exception of rabies, all occur outside of the United States.  Yet, without proper control measures, the viruses have the potential to hop from one location to the next and thrive in countries that were not previously infested, explained Rupprecht.

Prior to the development of modern medicine, rampant infections like rabies inspired tales of vampires, zombies, and werewolves.  Today, these tales persist in the form of movies like “Contagion,” and in the TV show ‘”The Walking Dead.”

But the journal’s new special edition highlights that brain-invading bugs are anything but fiction.

Though vaccines and medicine have helped to control these infections, there is still much to be done.   The collection calls on researchers to adopt new methods for understanding these manipulative parasites, which may ultimately shed light on the basic underpinnings of human and animal behavior.

“These infections are preventable things and if more efforts could be focused on this research, there could be quite an impact,” said Fiore.

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Canada’s Ivey PMI index unexpectedly fell in November

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South Africa military plane crashes in mountains

JOHANNESBURG (AP) — A South African military aircraft on an unknown mission to an area near the village where former President Nelson Mandela lives crashed in a mountain range, officials said Thursday. It was unclear whether there were any survivors.

The Douglas DC-3 Dakota, a twin-propeller aircraft, had taken off from Pretoria’s Waterkloof Air Force Base on Wednesday night, said Brig. Gen. Xolani Mabanga, a military spokesman. On Thursday morning, soldiers found the wreckage of the airplane in the Drakensberg mountains near Ladysmith in KwaZulu-Natal province, some 340 kilometers (210 miles) southeast of the air base, Mabanga said.

Mabanga said soldiers had been sent to the scene to look for survivors. Mabanga said he did not know what the mission of the aircraft was, though it had planned to land in Mthatha in the country’s Eastern Cape. Siphiwe Dlamini, a Defense Ministry spokesman, declined to immediately comment Thursday morning.

Mthatha is about 30 kilometers (17 miles) north of Qunu, the village where Mandela now lives after retiring from public life. South Africa‘s military remains largely responsible for the former president’s medical care. However, military officials declined to say whether those on board had any part in caring for Mandela.

In November, another South African military flight crash landed at Mthatha, sending several people to the hospital with injuries. However, at that time, the military denied that those on board had anything to do with Mandela’s care.

Mandela, 94, was imprisoned for nearly three decades for his fight against apartheid before becoming the nation’s president in the country’s first fully democratic vote in 1994.

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Jon Gambrell can be reached at www.twitter.com/jongambrellAP .

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Austrian farmers dip into Internet “milking” craze

VIENNA (Reuters) – Dumping a bottle of milk over your head and filming it for a video post on the Internet has become a popular youth craze, but Austrian farmers say the spillage is a crying shame.

“Milking”, as the trend is known, is among a variety of tongue-in-cheek stunts in which young people shoot pictures or videos of themselves posing as owls, planks of wood, or famous people and then share them on YouTube and other social media.

Austria’s AMA farm lobby on Wednesday launched its own “true milking” campaign to decry the wanton waste of dairy resources and to encourage consumers to drink it instead.

“At a time when too much food already lands in the trash, it is worth questioning dumping milk. This is a valuable product of nature that our farmers provide daily with lots of love and labor,” AMA milk marketing manager Peter Hamedinger said.

Milking has become an Internet hit, with one video from Newcastle in England getting more than half a million clicks on YouTube. http://www.youtube.com/watch?v=qtJPAv1UiAE

AMA’s marketing arm said the milking craze seemed to reflect a strange youthful protest against authority. It sought to one-up the video trend with its own clip featuring a young man who holds a carton of milk high above his head and drinks the contents without spilling a drop.

http://www.youtube.com/watch?v=EsJ3OsP1Fks&feature=youtu.be

“In line with the nature of the medium, this message is not communicated in a commercial way and absolutely not with finger pointing, but rather with a wink of the eye for the Internet generation,” the farm products board said in a statement.

(Reporting by Michael Shields, editing by Paul Casciato)

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Watch: World’s Oldest Person Dies at 116

Home > Video > Most Popular

NYC Man Pushed on Subway Tracks, Killed by Train

NYC Man Pushed on Subway Tracks, Killed by Train

Police are looking for suspect who they say pushed another man off a subway platform.

NYC Subway Fight Caught on Tape

NYC Subway Fight Caught on Tape

Video shows a group of teenage girls scuffling with police officers.

Bystanders Pull Mom, Son From Subway Tracks

Bystanders Pull Mom, Son From Subway Tracks

Frightening moment caught on tape shows straphangers rushing to aid of mother, son.

Caught on Tape: Man Run Over by Subway

Caught on Tape: Man Run Over by Subway

An Oregon man survives an encounter with two trains after falling on the tracks.

Arrest in Deadly Subway Push

Arrest in Deadly Subway Push

A man is held for questioning in deadly subway shove.

Kate Middleton Spends Second Night in Hospital

Kate Middleton Spends Second Night in Hospital

Lama Hasan has the latest on the health of the Duchess of Cambridge.

Alaska Barista Murder Suspect Found Dead

Alaska Barista Murder Suspect Found Dead

FBI believes Israel Keyes was linked to seven other killings across the U.S.

Kate Middleton Pregnant: Royal Couple Expecting

Kate Middleton Pregnant: Royal Couple Expecting

Prince William and his wife announce they are expecting their first child.

Judge Orders Return of Adopted Girl to Biological Father

Judge Orders Return of Adopted Girl to Biological Father

Adoptive Utah couple has 60 days to return child given up by mother without father’s knowledge.

Kate Middleton Pregnant, Rushed to Hospital

Kate Middleton Pregnant, Rushed to Hospital

The Duchess of Cambridge, expecting first child, diagnosed with hyperemesis gravidarum.

Alaska’s Missing Barista: Arrest Made

Alaska’s Missing Barista: Arrest Made

Israel Keyes was arrested in disappearance of 18-year-old Samantha Koenig.

Missing Alaska Barista Had Past Restraining Order

Missing Alaska Barista Had Past Restraining Order

Samantha Koenig’s father says he thinks he knows who holds the key to the case.

Twins Caught Fighting in the Womb

Twins Caught Fighting in the Womb

MRI footage shows twin fetuses kicking each other.

Dad Fights for Daughter Given Up for Adoption

Dad Fights for Daughter Given Up for Adoption

John Wyatt is in a custody dispute with ex-girlfriend over baby Emma.

Barista Kidnapped at Gunpoint

Barista Kidnapped at Gunpoint

Police are searching for a teen taken against her will by coffee shop robber.

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